Having begun the year with a hugely impressive 14-2 win over Liverpool Ladies at the start of the month, Leanne Skarrat and her side will be looking to maintian their unbeaten run in the league thus far when they welcome Cheshire to Platt Lane on Saturday afternoon.
With the women's side dropping just two points all season, they are three points clear at the top of the Women's Super Series, and Saturday's opponents Cheshire will be looking to keep challenging Manchester and University of Liverpool at the top of the table.
Cheshire are the only team to walk away with a point against the Blues this season - it ended in a 3-3 draw, with top scorer Katy Morris netting alongside Sasha Adamson and Leah Hartshone.
A win on Sunday would help cement Manchester's commanding position at the helm of the Super Series, but it's sure to be an intriguing tie having shared the spoils earlier in the season.
Kick off is scheduled for 15:00 at the Platt Lane Sports Complex.